Sulfatide inhibits fibroblast growth, activation and oxidative stress induced by ectopic insulin.

Allan Roeske-Nielsen,Jan-Eric Månsson, Hasim Tekin, Klaus Rieneck,Klaus Bendtzen,Karsten Buschard

Diabetes, obesity & metabolism（2023）

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摘要

Sulfatide strongly inhibits fibroblast growth. We therefore suggest the addition of sulfatide to injectable commercial insulin formulations, which would reduce adverse fibroblast growth and improve well-being in patients with diabetes.

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关键词

beta cell devices, fibroblasts, sphingolipids, sulfatide, type 1 diabetes

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