Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.

Chuanxia Liu,Jinhan Zhou,Shanshan Zhang, Ji Fu, Yining Li,Yilong Hao,Jian Yuan,Fan Tang,Weili Ge,Hong He,Qianming Chen

Oral diseases（2023）

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摘要

The results indicated that MSCs-derived IL-6-promoted tumour invasion and metastasis via JAK-STAT3 signalling. Blockade of this pathway by tocilizumab may be a potential treatment to improve the prognosis and survival rate of patients with OSCC.

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关键词

cancer progression, interleukin 6, mesenchymal stem cell, metastasis, oral squamous cell carcinoma

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