Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation.

Ashti M Shah,Ali Mubin Aral,Ruben Zamora, Nitin Gharpure,Fayten El-Dehaibi,Fatih Zor,Yalcin Kulahci,Huseyin Karagoz,Derek A Barclay,Jinling Yin,Warren Breidenbach, Dmitry Tuder,Vijay S Gorantla,Yoram Vodovotz

Frontiers in immunology（2023）

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摘要

Thus, NR, while considered necessary for restoring graft function, may also result in dysregulated and mis-compartmentalized inflammation post-VCA and therefore necessitate mitigation strategies. Our novel computational pipeline may also yield translational, spatiotemporal insights in other contexts.

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关键词

peripheral nerve repair,inflammation,cross-tissue

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