The Action and Mechanism of Trehalose on GATA4 Autophagy Degradation and Ventricular Remodeling.

Qiaoying Chai, Wei Zhang,Lijuan Gao,Yingtao Yang,Mengdan Miao,Da Liu,Lixia Chen,Mingqi Zheng,Shuanli Xin

Discovery medicine（2023）

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摘要

Trehalose significantly abates myocardial hypertrophy and pressure overload-induced cardiomyocyte apoptosis in mice. The cardioprotective effect of trehalose on enhanced autophagy is attributed, at least in part, to the promotion of autophagic degradation of GATA4.

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关键词

gata4 autophagy degradation,ventricular remodeling,trehalose

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