Single-cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation.

Jie Yang,Hu Tan,Mengjia Sun,Renzheng Chen,Zhao Jian,Yuanbin Song,Jihang Zhang,Shizhu Bian,Bo Zhang,Yi Zhang,Xubin Gao,Zhen Chen,Boji Wu,Xiaowei Ye,Hailin Lv,Zhen Liu,Lan Huang

Clinical and translational medicine（2023）

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摘要

This study highlights the decrease in the anticoagulant status of EECs in LAA as a potential mechanism underlying the propensity for thrombosis, which may aid the development of anticoagulation therapeutic approaches targeting functionally distinct cell subsets or molecules during AF.

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关键词

ADAMTS1, atrial fibrillation, endocardial endothelial cells, single-cell RNA-sequencing, TFPI family, thrombogenesis

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