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So tell me… does this tracheal aspirate culture indicate "infection" or "colonization"?

Pediatric pulmonology(2023)

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Pediatric PulmonologyEarly View EDITORIAL So tell me… does this tracheal aspirate culture indicate “infection” or “colonization”? Andrea M. Prinzi PhD, Andrea M. Prinzi PhD orcid.org/0000-0003-2949-5484 BioMérieux, Salt Lake City, Utah, USA Contribution: Conceptualization, Writing - original draft, Writing - review & editingSearch for more papers by this authorChristopher D. Baker MD, Corresponding Author Christopher D. Baker MD [email protected] orcid.org/0000-0002-1171-563X University of Colorado School of Medicine, Aurora, Colorado, USA Correspondence Christopher D. Baker, MD, Department of Pediatrics, Section of Pulmonary and Sleep Medicine, University of Colorado School of Medicine, 13123 E. 16th Ave Box B-395, Aurora, CO 80045, USA. Email: [email protected] Contribution: Conceptualization, Writing - original draft, Writing - review & editing, SupervisionSearch for more papers by this author Andrea M. Prinzi PhD, Andrea M. Prinzi PhD orcid.org/0000-0003-2949-5484 BioMérieux, Salt Lake City, Utah, USA Contribution: Conceptualization, Writing - original draft, Writing - review & editingSearch for more papers by this authorChristopher D. Baker MD, Corresponding Author Christopher D. Baker MD [email protected] orcid.org/0000-0002-1171-563X University of Colorado School of Medicine, Aurora, Colorado, USA Correspondence Christopher D. Baker, MD, Department of Pediatrics, Section of Pulmonary and Sleep Medicine, University of Colorado School of Medicine, 13123 E. 16th Ave Box B-395, Aurora, CO 80045, USA. Email: [email protected] Contribution: Conceptualization, Writing - original draft, Writing - review & editing, SupervisionSearch for more papers by this author First published: 06 June 2023 https://doi.org/10.1002/ppul.26534Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Prinzi AM, Parker SK, Curtis DJ, Ziniel SI. The pediatric endotracheal aspirate culture survey (PETACS): examining practice variation across pediatric microbiology laboratories in the United States. J Clin Microbiol. 2021; 59(3):e02232-20. 2Prinzi A, Parker SK, Thurm C, Birkholz M, Sick-Samuels A. Association of endotracheal aspirate culture variability and antibiotic use in mechanically ventilated pediatric patients. JAMA Network Open. 2021; 4(12):e2140378. 3Foglia E, Meier MD, Elward A. Ventilator-associated pneumonia in neonatal and pediatric intensive care unit patients. Clin Microbiol Rev. 2007; 20(3): 409-425, table of contents. 4Willson DF, Conaway M, Kelly R, Hendley JO. The lack of specificity of tracheal aspirates in the diagnosis of pulmonary infection in intubated children. Pediatr Critical Care Med. 2014; 15(4): 299-305. 5Wasserman MG, Graham RJ, Mansbach JM. Airway bacterial colonization, biofilms and blooms, and acute respiratory infection. Pediatr Critical Care Med. 2022; 23(10): e476-e482. 6Prinzi AM, Wattier RL, Curtis DJ, et al. Impact of organism reporting from endotracheal aspirate cultures on antimicrobial prescribing practices in mechanically ventilated pediatric patients. J Clin Microbiol. 2022; 60(11):e0093022. 7Steuart R, Ale GB, Woolums A, et al. Respiratory culture organism isolation and test characteristics in children with tracheostomies with and without acute respiratory infection. Pediatr Pulmonol. 2023; 58(5): 1481-1491. 8Sick-Samuels AC, Fackler JC, Berenholtz SM, Milstone AM. Understanding reasons clinicians obtained endotracheal aspirate cultures and impact on patient management to inform diagnostic stewardship initiatives. Infect Control Hosp Epidemiol. 2020; 41(2): 240-242. 9Sick-Samuels AC, Linz M, Bergmann J, et al. Diagnostic stewardship of endotracheal aspirate cultures in a PICU. Pediatrics. 2021; 147(5):e20201634. 10Chiotos K, Marshall D, Kellom K, et al. Mixed-methods process evaluation of a respiratory-culture diagnostic stewardship intervention. Infec Control Hospital Epidemiol. 2023; 44: 191-199. 11Zaidi AK, Reller LB. Rejection criteria for endotracheal aspirates from pediatric patients. J Clin Microbiol. 1996; 34(2): 352-354. 12Yalamanchi S, Saiman L, Zachariah P. Decision-making around positive tracheal aspirate cultures: the role of neutrophil semiquantification in antibiotic prescribing. Pediatr Critical Care Med. 2019; 20(8): e380-e385. 13Musgrove MA, Kenney RM, Kendall RE, et al. Microbiology comment nudge improves pneumonia prescribing. Open Forum Infect Dis. 2018; 5(7): ofy162. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation
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关键词
aspirate culture,infection”,tracheal,colonization”
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