谷歌浏览器插件
订阅小程序
在清言上使用

Design, Synthesis, Antimicrobial Evaluation of Novel 2-Oxo-4-substituted Aryl-Azetidine Benzotriazole Derivatives.

Vijayshri Rokde,Kishor Danao, Juhi Nimje,Deweshri Nandurkar, Tiksha Yerne, Priyanka Yadav,Ujwala Mahajan

Chemistry & biodiversity(2023)

引用 0|浏览10
暂无评分
摘要
A series of compounds was synthesized and characterized to explore new antimicrobial agents. These compounds were evaluated by using the agar cup plate method. The most active compound exhibited a zone of inhibition 18 & PLUSMN;0.09 mm and 19 & PLUSMN;0.09 mm against E. Coli and S. aureus, respectively. To gain insights into the intermolecular interactions, molecular docking studies were performed at the active site of the glucosamine fructose 6 phosphate synthase (GlcN 6 p) enzyme (PDB Id: 1XFF). The results of the molecular docking studies are in agreement with the pharmacological evaluation with potent compounds, exhibiting docking scores of -11.2. However, deformability, B-factor and covariance computations showed a result that the most active compound favored molecular connections with the protein. Therefore, our research is important for the development of antimicrobial agents
更多
查看译文
关键词
benzotriazole,azetidine,microwave,molecular docking,antimicrobial activity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要