Glucose metabolism and function of CD4 + Tregs are regulated by the TLR8/mTOR signal in an environment of SKOV3 cell growth.

Ming Wu, Xin Fu,Rui Xu,Shuna Liu,Rong Li,Juan Xu,Wenwen Shang,Xian Chen,Ting Wang,Fang Wang

Cancer medicine（2023）

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摘要

These findings imply that activation of the TLR8 signal inhibits glucose metabolism in CD4 Tregs by downregulating mTOR signaling, thereby reversing the immunosuppressive function of these cells in an OC cell growth environment.

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关键词

glucose metabolism, mammalian target of rapamycin, ovarian cancer, regulatory T-cells, Toll-like receptor 8

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