Metabolism of ropinirole is mediated by several canine CYP enzymes.
Veterinary medicine and science(2023)
Abstract
Although human metabolism of ropinirole is mainly mediated through CYP1A2, the current study shows that several canine CYP isoforms are able to contribute to the clearance of ropinirole in dogs. This is expected to reduce a possible impact of canine CYP1A2 polymorphism on ropinirole pharmacokinetics.
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Key words
CYP, dog, in vitro, ropinirole
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