Lymphocyte transformation test in the diagnosis of adult fish-induced enterocolitis syndrome.

Food protein-induced enterocolitis syndrome (FPIES) is a non–IgE-mediated gastrointestinal food allergy.1 The diagnosis of FPIES is primarily based on the clinical history, although its gastrointestinal symptoms are shared with many other conditions, complicating its differential diagnosis. An oral food challenge is indicated when the diagnosis is unclear, or to determine tolerance, with a potential risk to the patient.2