A novel polygenic risk score improves prognostic prediction of heart failure with preserved ejection fraction in the Chinese Han population.

Yi Han,Jiapeng Lu,Bowang Chen,Xi Li,Hao Dai,Lihua Zhang,Xiaofang Yan,Jiamin Liu,Haibo Zhang, Xin Fu,Qin Yu,Jie Ren,Hanbin Cui,Yan Gao,Jing Li

European journal of preventive cardiology（2023）

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摘要

The HF-PRS comprising 69 genetic variants provided an improvement of prognostic power over the contemporary risk scores and NT-proBNP in HFpEF patients.

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关键词

Heart failure with preserved ejection fraction (HFpEF), Polygenic risk score (PRS), Microarray analysis, Prediction, Prognosis, Risk of death

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