Gut microbial GABAergic signaling improves stress-associated innate immunity to respiratory viral infection

Yanan Gao,Zihao Liang, Bingyong Mao, Xudong Zheng,Jinjun Shan,Cuiyuan Jin,Shijia Liu,Narasaiah Kolliputi,Yugen Chen,Feng Xu,Liyun Shi

Journal of advanced research（2023）

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摘要

•Psychological stress exacerbates respiratory viral infection via disturbing gut microbiome.•Psychological stress specifically reduces Lactobaceace abundance and GABA level.•Microbial GABA regulates AMs homeostasis via the αKG/TET2/PPARγ axis.•Replenishment of GABA-metabolizing bacteria reverses adverse effect of stress on viral pneumonia.

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Psychological stress,Gut microbiome,Alveolar macrophages,GABA,Respiratory viral infection

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