Impact of age on survival according to molecular tumor findings in children and adolescents with soft-tissue and bone sarcoma: The BIOSCA project

Emmanuel Desandes,Eve Lapouble,Brigitte Lacour,Sandra Guissou,Stéphanie Goujon,Anne-Sophie Defachelles, Valérie Marechal,Nathalie Gaspar,Anne Gomez-Mascard,Marie Karanian,Perrine Marec-Berard,Véronique Minard-Colin,Daniel Orbach,Marie-Dominique Tabone,Olivier Delattre,Gaelle Pierron

Cancer epidemiology（2023）

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摘要

•Adolescents had worse outcome for undifferentiated small round cell sarcoma (USRCS) and alveolar rhabdomyosarcoma (ARMS).•5yOS was worse among CIC-rearranged USRCS cases (47% [21–69]) as compared to other USRCS.•5yOS was worse among PAX3::FOXO1 ARMS patients (44% [32–55]) as compared to PAX7::FOXO1 ARMS cases (88% [61–97]).•Age was an independent prognostic factor of outcome only in patients with USRCS.•Association between age and survival of patients with ARMS could be explained by prevalence of PAX3::FOXO1.

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ASPS,ARMS,AYA,BIOSCA,CI95%,DSRCT,EpSSG,ERMS,ES,EWS,FaR-RMS,FDFSP,ICCC-3,ICDO-3,LGFMS,MPNST,RNCE,RNIPP,SEER,SS,OS,US,USRCS,WHO

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