Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus-infected rhesus macaques.

Julian B Hattler,Derek L Irons,Jiangtao Luo,Woong-Ki Kim

Brain and behavior（2023）

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摘要

These findings show a shift in CCR5-positive cell types in the brain during SIV pathogenesis with an increase in the number of CCR5+ CD8 T cells, and downregulated CCR5 expression on infected PVMs, likely through ERK1/2-driven, clathrin-mediated endocytosis.

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关键词

CCR5, CD8 T lymphocytes, endocytosis, HIV, perivascular macrophages, SIV

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