Cured HCV patients with suboptimal hepatitis B vaccine response exhibit high self-reactive immune signatures.

Ming-Ju Zhou,Chao Zhang,Yuan-Jie Fu,Haiyan Wang,Yingjie Ji, Xia Huang,Lin Li, Ye Wang,Song Qing,Yanze Shi,Lili Shen,You-Yuan Wang,Xiao-Yu Li,Yuan-Yuan Li,Si-Yuan Chen,Cheng Zhen,Ruonan Xu,Ming Shi,Fu-Sheng Wang,Yongqian Cheng

Hepatology communications（2023）

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摘要

Our data suggest that cured HCV patients exhibit persistent perturbations in the adaptive immune system, among which highly self-reactive immune signatures may contribute to a suboptimal hepatitis B vaccine response.

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关键词

hcv patients,immune signatures,vaccine,self-reactive

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