Inhibition of IL-4/STAT6/IRF4 signaling reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps.

Jingcai Chen, Shan Chen,Guoqing Gong,Fan Yang,Jianjun Chen,Yanjun Wang

International immunopharmacology（2023）

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摘要

In eosinophilic nasal polyps, IL-4 induces STAT6 signaling to upregulate IRF4 expression in epithelial cells and macrophages. IL-4 promotes EMT of hNECs through the STAT6/IRF4 signaling pathway. IL-4-induced M2 macrophages enhanced EMT of hNECs. Inhibition of STAT6 can downregulate the expression of IRF4 and suppress the EMT process, thus providing a new strategy for the treatment of nasal polyps.

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关键词

Chronic rhinosinusitis,Nasal polyps,Interleukin-4,Signal transducer and activator of transcription 6,Interferon regulatory factor 4,Epithelial-to-mesenchymal transition

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