Amamine, an Isoquinoline Alkaloid from the Kitasatospora Sp. HGTA304

Teppei Kawahara, Marin Ueda,Naoki Kishimoto, Tae Yasutake,Shogo Misumi,Hari Prasad Devkota,Mikiyo Wada

Journal of antibiotics（2023）

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摘要

Amamine (1), a new isoquinoline alkaloid, was isolated from the culture extract of an actinomycete Kitasatospora sp. HGTA304. The structure of 1 was determined by NMR and MS analyses in combination with UV data. Compound 1 displayed α-glucosidase inhibitory potential (IC50 value of 56 μM) compared with acarbose (IC50 value of 549 μM) as standard.

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Drug discovery,Medical research,Life Sciences,general,Microbiology,Medicinal Chemistry,Organic Chemistry,Bacteriology,Bioorganic Chemistry

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