Effects of RS17053 on α 1 -adrenoceptors in rat vas deferens and aorta.

Results in rat vas deferens demonstrate low potency of RS17053 at α -adrenoceptors, but results from rat aorta can only be explained as demonstrating α -adrenoceptor antagonism by RS17053. RS17053 may be a useful pharmacological tool when reclassified as a mainly α - and to a lesser extent α -adrenoceptor antagonist with little effect at α -adrenoceptors.