Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults.

HomeCirculation: Genomic and Precision MedicineAhead of PrintContemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults Open AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toOpen AccessResearch ArticlePDF/EPUBContemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults Rodrigo Guarischi-Sousa, Elias Salfati, Pik Fang Kho, Kruthika R. Iyer, Austin T. Hilliard, David M. Herrington, Philip S. Tsao, Shoa L. Clarke and Themistocles L. Assimes Rodrigo Guarischi-SousaRodrigo Guarischi-Sousa https://orcid.org/0000-0002-3614-9996 Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.) Search for more papers by this author , Elias SalfatiElias Salfati Scripps Research Translational Institute at Scripps Research, La Jolla, CA (E.S.). Search for more papers by this author , Pik Fang KhoPik Fang Kho https://orcid.org/0000-0001-7831-6062 Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.) Search for more papers by this author , Kruthika R. IyerKruthika R. Iyer Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.) Search for more papers by this author , Austin T. HilliardAustin T. Hilliard VA Palo Alto Health Care System, CA (A.T.H., P.S.T., S.L.C., T.L.A.). Search for more papers by this author , David M. HerringtonDavid M. Herrington Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.). Search for more papers by this author , Philip S. TsaoPhilip S. Tsao https://orcid.org/0000-0001-7274-9318 Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.) Department of Epidemiology and Population Health (P.S.T., T.L.A.) Cardiovascular Institute (P.S.T., T.L.A.) VA Palo Alto Health Care System, CA (A.T.H., P.S.T., S.L.C., T.L.A.). Search for more papers by this author , Shoa L. ClarkeShoa L. Clarke https://orcid.org/0000-0002-6592-1172 Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.) Department of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, CA (S.L.C.). VA Palo Alto Health Care System, CA (A.T.H., P.S.T., S.L.C., T.L.A.). *S. Clarke and T. Assimes contributed equally. Search for more papers by this author and Themistocles L. AssimesThemistocles L. Assimes Correspondence to: Themistocles L. Assimes, MD, PhD, Palo Alto VA Hospital, 3801 Miranda Ave, Palo Alto, CA 94304. Email E-mail Address: [email protected] https://orcid.org/0000-0003-2349-0009 Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.) Department of Epidemiology and Population Health (P.S.T., T.L.A.) Cardiovascular Institute (P.S.T., T.L.A.) VA Palo Alto Health Care System, CA (A.T.H., P.S.T., S.L.C., T.L.A.). *S. Clarke and T. Assimes contributed equally. Search for more papers by this author Originally published6 Jul 2023https://doi.org/10.1161/CIRCGEN.122.004047Circulation: Genomic and Precision Medicine. 2023;0:e004047Footnotes*S. Clarke and T. Assimes contributed equally.For Sources of Funding and Disclosures, see page XXX.Correspondence to: Themistocles L. Assimes, MD, PhD, Palo Alto VA Hospital, 3801 Miranda Ave, Palo Alto, CA 94304. Email [email protected]edu eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. 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This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.https://doi.org/10.1161/CIRCGEN.122.004047PMID: 37409455 Originally publishedJuly 6, 2023 Keywordsbody mass indexprevalenceodds ratiolow-density lipoproteincoronary artery diseasePDF download Advertisement SubjectsCoronary Artery DiseaseGenetic, Association StudiesPrimary PreventionRace and EthnicityRisk Factors