Vaccine-boosted CAR T Crosstalk with Host Immunity to Reject Tumors with Antigen Heterogeneity

Leyuan Ma, Alexander Hostetler,Duncan M. Morgan,Laura Maiorino,Ina Sulkaj, Charles A. Whittaker, Alexandra Neeser, Ivan Susin Pires,Parisa Yousefpour, Justin Gregory,Kashif Qureshi, Jonathan Dye, Wuhbet Abraham,Heikyung Suh, Na Li, J. Christopher Love,Darrell J. Irvine

Regular and Young Investigator Award Abstracts（2023）

Cited 17|Views30

Key words

chimeric antigen receptor T cell,CAR T,vaccine,antigen spreading,IFN-γ,cancer,solid tumor,antigen loss,antigenic heterogeneity,tumor heterogeneity,immunotherapy

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