GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosis.

Francesca Gobbo,Maria Zingariello,Paola Verachi,Mario Falchi,Francesca Arciprete,Fabrizio Martelli,Angelo Peli,Maria Mazzarini,Jeff Vierstra,Carolyn Mead-Harvey,Amylou C Dueck,Giuseppe Sarli,Stefano Nava,Giacomo Sgalla,Luca Richeldi,Anna Rita Migliaccio

bioRxiv : the preprint server for biology（2023）

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摘要

Lungs from IPF patients contain many GATA1 negative immune MK mice are the first genetic model with a pathophysiology similar to IPF lungs mice contain defective immune MK with high P-sel, TGF-β and CXCL1 ablation or P-sel/TGF-β/CXCL1 inhibition rescues fibrosis in lung.

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关键词

idiopathic pulmonary fibrosis,immune-megakaryocytes

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