HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide.

Evgeny Deforzh,Prakash Kharel,Anton Karelin,Pavel Ivanov,Anna M Krichevsky

bioRxiv : the preprint server for biology（2023）

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摘要

Our results demonstrate that HOXDeRNA overrides PRC2 repression of glioma core regulatory circuitry with RNA quadruplex structure. These findings help reconstruct the sequence of events underlying the process of astrocyte transformation and suggest a driving role for HOXDeRNA and a unifying RNA-dependent mechanism of gliomagenesis.

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关键词

cancerous transcription program,super-enhancers,genome-wide

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