Independent causal effect of remnant cholesterol on atherosclerotic cardiovascular outcomes: a Mendelian randomization study

K. Grzelakowska,D. Vine,S. Proctor,P. Raggi,J. Kubica,E. P. Navarese

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

This large-scale Mendelian randomization study showed a robust genetic causal association between RC and cardiovascular outcomes. The effect on CAD and MI is independent of LDL cholesterol. Early screening for RC along with long-term inhibition of RC should be the focus of future therapeutic interventions.

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关键词

atherosclerotic cardiovascular outcomes,remnant cholesterol,independent causal effect

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