Identifying key multi-modal predictors of incipient dementia in Parkinson's disease: a machine learning analysis and Tree SHAP interpretation.

G Peggy McFall,Linzy Bohn,Myrlene Gee,Shannon M Drouin,Harrison Fah,Wei Han,Liang Li,Richard Camicioli,Roger A Dixon

Frontiers in aging neuroscience（2023）

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摘要

Our data-driven protocol integrated RF classifier models and Tree SHAP applications to selectively identify and interpret early dementia risk factors in a well-characterized sample of initially non-demented persons with PD. Results indicate that leading dementia predictors derive from multiple complementary risk domains.

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关键词

Parkinson's disease, dementia, risk factors, biomarkers, random forest classifier, Tree SHapley Additive exPlanation

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