PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine.

Máté Bencsics,Bálint Bányai,Haoran Ke,Roland Csépányi-Kömi,Péter Sasvári,Françoise Dantzer,Najat Hanini,Rita Benkő,Eszter M Horváth

Frontiers in immunology（2023）

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摘要

Our results confirmed that T cell-specific PARP2 downregulation ameliorated LPS-induced colitis. The dampened TNFa production, decreased IL-17 production and the increased intestinal regulatory T cell number after LPS treatment may be also beneficial during inflammatory processes seen in IBD. By reducing oxidative-nitrative stress and PARP1 activation, T cell-specific PARP2 downregulation may also alleviate intestinal tissue damage.

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关键词

colitis, IBD, inflammatory bowel disease, PARP (poly(ADP-ribose) polymerase, PARP2, T lymphocyte, regulatory (Treg) cell

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