Circulating Tfr/Tfh cell imbalance may contribute to the immunopathogenesis of pemphigus

Journal of the European Academy of Dermatology and VenereologyEarly View LETTER TO THE EDITOR Circulating Tfr/Tfh cell imbalance may contribute to the immunopathogenesis of pemphigus Chuan Wang, Chuan Wang orcid.org/0000-0003-3079-8431 Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorHao Zhang, Hao Zhang Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorTingting Liu, Tingting Liu Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorZhenzhen Wang, Zhenzhen Wang orcid.org/0000-0001-5927-2471 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorYuan Zhang, Yuan Zhang Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorGongqi Yu, Gongqi Yu Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorNa Wang, Na Wang orcid.org/0000-0001-9177-5749 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorQiji Liu, Qiji Liu Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaSearch for more papers by this authorHong Liu, Corresponding Author Hong Liu [email protected] orcid.org/0000-0003-4488-0372 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China Correspondence Furen Zhang and Hong Liu, Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, No. 27397 Jingshi Road, Jinan, Shandong Province, 250022, China. Email: [email protected] and [email protected]Search for more papers by this authorFuren Zhang, Corresponding Author Furen Zhang [email protected] Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China Correspondence Furen Zhang and Hong Liu, Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, No. 27397 Jingshi Road, Jinan, Shandong Province, 250022, China. Email: [email protected] and [email protected]Search for more papers by this author Chuan Wang, Chuan Wang orcid.org/0000-0003-3079-8431 Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorHao Zhang, Hao Zhang Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorTingting Liu, Tingting Liu Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorZhenzhen Wang, Zhenzhen Wang orcid.org/0000-0001-5927-2471 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorYuan Zhang, Yuan Zhang Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorGongqi Yu, Gongqi Yu Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorNa Wang, Na Wang orcid.org/0000-0001-9177-5749 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSearch for more papers by this authorQiji Liu, Qiji Liu Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaSearch for more papers by this authorHong Liu, Corresponding Author Hong Liu [email protected] orcid.org/0000-0003-4488-0372 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China Correspondence Furen Zhang and Hong Liu, Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, No. 27397 Jingshi Road, Jinan, Shandong Province, 250022, China. Email: [email protected] and [email protected]Search for more papers by this authorFuren Zhang, Corresponding Author Furen Zhang [email protected] Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China Correspondence Furen Zhang and Hong Liu, Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, No. 27397 Jingshi Road, Jinan, Shandong Province, 250022, China. Email: [email protected] and [email protected]Search for more papers by this author First published: 17 July 2023 https://doi.org/10.1111/jdv.19338Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet (London, England). 2019; 394(10201): 882–894. 2Kridin K, Schmidt E. Epidemiology of pemphigus. JID Innov. 2021; 1(1):100004. 3Scarsella L, Pollmann R, Amber KT. Autoreactive T cells in pemphigus: perpetrator and target. Ital J Dermatol Venerol. 2021; 156(2): 124–133. 4Wang B, Zhu J, Ma X, Qiu S, Pan B, Zhou J, et al. Tfr-Tfh index: a new predicator for recurrence of hepatocellular carcinoma patients with HBV infection after curative resection. Clin Chim Acta. 2020; 511: 282–290. 5Wang X, Yang C, Xu F, Qi L, Wang J, Yang P. Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis. Clin Exp Med. 2019; 19(1): 55–64. 6Wei Y, Feng J, Hou Z, Wang XM, Yu D. Flow cytometric analysis of circulating follicular helper T (Tfh) and follicular regulatory T (Tfr) populations in human blood. Methods Mol Biol (Clifton, N.J.). 2015; 1291: 199–207. 7Kentaro O, Taku F, Chunbing L, Ryo A, Yusuke M, Setsuya A. Possible roles of CXCL13/CXCR5 axis in the development of bullous pemphigoid. J Dermatol. 2021; 48(3): 353–359. 8Niu Q, Huang Z, Wu X, Jin Y, An Y, Li Y, et al. Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis. Arthritis Res Ther. 2018; 20(1): 200. 9Li L, Yang SH, Yao Y, Xie YQ, Yang YQ, Wang YH, et al. Block of both TGF-beta and IL-2 signaling impedes Neurophilin-1(+) regulatory T cell and follicular regulatory T cell development. Cell Death Dis. 2016; 7:e2439. 10Wu X, Wang Y, Huang R, Gai Q, Liu H, Shi M, et al. SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation. Science. 2020; 369(6506): 984–988. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation