Regulation of coagulation activation in newly diagnosed AML by the heme enzyme myeloperoxidase

Florian Langer, Hanna Quick,Antonia Beitzen-Heineke,Snjezana Janjetovic, Jonathan Mäder,Carina Lehr,Carsten Bokemeyer,Piotr Kuta,Thomas Renné,Walter Fiedler,Lennart Beckmann,Felix Klingler,Christina C. Rolling

Thrombosis Research（2023）

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摘要

Our study indicates that catalytically active MPO released by circulating myeloblasts regulates TF-dependent coagulation in patients with newly diagnosed AML in a CD18-dependent manner.

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关键词

Acute myeloid leukemia, Tissue factor, Myeloperoxidase, D-dimer, Coagulation

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