Increased risk of rheumatoid arthritis in patients with asthma: a genetic association study using two-sample Mendelian randomization analysis.

Genetically predicted AOA predisposes patients to an increased risk of rheumatoid arthritis, but has no causal effects on osteoarthritis, gout, and ankylosing spondylitis. The result of COA on rheumatoid arthritis is suggestive of potential causal relationship but needs to be confirmed in further studies.