A Novel HPV/Host DNA Methylation-Score and Detection of Cervical Adenocarcinoma.

Ana Gradissimo,Megan A Clarke,Xiaonan Xue,Philip E Castle,Tina R Raine-Bennett,Mark Schiffman,Nicolas Wentzensen,Howard D Strickler,Robert D Burk

Journal of the National Cancer Institute（2023）

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摘要

HPV16/18/45-infected women with Methylation-Scores in the highest quartile had very high odds of AIS/ADC, suggesting they may warrant careful histologic evaluation of the cervical transition zone (eg, conization or LEEP).

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