Potential risk of tamoxifen: gut microbiota and inflammation in mice with breast cancer.

Hailong Li,Xiufei Gao,Yian Chen,Mengqian Wang,Chuchu Xu,Qinghong Yu, Ying Jin,Jiaqing Song, Qi Zhu

Frontiers in oncology（2023）

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摘要

Tamoxifen treatment significantly altered gut microbiota and increased inflammation in the breast cancer xenograft mice model. This may be related to tamoxifen-induced intestinal epithelial barrier damage and TLR5 up-regulation.

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关键词

tamoxifen,gut microbiota,breast cancer,inflammation

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