Ceramide-1-phosphate alleviates high-altitude pulmonary edema by stabilizing circadian ARNTL-mediated mitochondrial dynamics

Liuyang Tian,Chenghui Zhao,Yan Yan,Qian Jia,Saijia Cui,Huining Chen,Xiaolu Li,Hongfeng Jiang,Yongming Yao,Kunlun He,Xiaojing Zhao

Journal of Advanced Research（2023）

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摘要

•CERK inhibition worsened the severity of HAPE, while exogenous C1P treatment had a protective effect on HAPE.•CERK inhibition disrupted the circadian rhythm by inducing ARNTL autophagic degradation.•CERK inhibition reduced ARNTL expression, affecting mitochondrial dynamics, causing oxidative stress and mitophagy defects.•Exogenous C1P has the potential to be an effective therapeutic strategy for preventing or treating HAPE.

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关键词

Ceramide-1-phosphate,Hypoxia,Pulmonary edema,Circadian rhythm,Mitochondrial dynamics

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