Compound Kushen Injection inhibits epithelial-mesenchymal transition of gastric carcinoma by regulating VCAM1 induced by the TNF signaling pathway.

Zhihong Huang,Chao Wu,Wei Zhou,Shan Lu,Yingying Tan,Zhishan Wu,Rongli You,Antony Stalin,Fengying Guo,Jingyuan Zhang,Pengyun Liu,Wei Wang,Xiaoxia Duan,Leiming You,Jiarui Wu

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

CKI can effectively inhibit GC growth and metastasis, improve body's immunity, and protect normal tissues from damage. The molecular mechanism by which CKI inhibits metastasis of GC is by regulating VCAM1 induced by the TNF signaling pathway to inhibit EMT of GC. Our results provide an important clue to clarify precisely the multi-scale molecular mechanism of CKI in the treatment of GC.

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关键词

gastric carcinoma,compound kushen injection,vcam1,epithelial-mesenchymal

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