PS4 - 22. Endogenous formation of N ε -(Carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis

Katrien H.J. Gaens,Petra M.G. Niessen,Sander S. Rensen,Wim A. Buurman,Jan Willem M. Greve,Ann Driessen,Marcel M.G. Wolfs,Marten H. Hofker,Johanne G. Bloemen,Cornelis H. Dejong,Coen D.A. Stehouwer,Casper G. Schalkwijk

Nederlands Tijdschrift voor Diabetologie（2015）

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摘要

Increased lipid peroxidation and inflammation are major factors in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A lipoxidation product that could play a role in the induction of hepatic inflammation is N ε -(Carboxymethyl)lysine (CML). The aim of this study was to investigate the relationship between steatosis and CML, and to study the role of CML in hepatic inflammation.

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关键词

Inflammatory Marker,Lipid Accumulation,Obese Individual,Hepatic Steatosis,Nonalcoholic Fatty Liver Disease

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