Higenamine attenuates cardiac fibroblast abstract and fibrosis via inhibition of TGF-β1/Smad signaling

•Higenamine ameliorates cardiac remodeling and/or dysfunction in a variety of mouse models.•Higenamine attenuates cardiac fibrosis.•Higenamine suppresses cardiac fibroblast activation and matrix protein expression.•This effect is dependent on TGF-β1/Smad signaling but not β2-adrenergic receptor, a previously known target of Higenamine.