Cell-Free DNA as a Biomarker in a Rodent Model of Chlorpyrifos Poisoning Causing Mitochondrial Dysfunction.

Shih-Han Kao,Frances S Shofer,John C Greenwood,Oladunni Alomaja,Abhay Ranganathan,Sarah Piel,Clementina Mesaros,Samuel S Shin,Johannes K Ehinger,Todd J Kilbaugh,David H Jang

Journal of medical toxicology : official journal of the American College of Medical Toxicology（2023）

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摘要

In our study, we found that the total cfDNA concentration may serve as a more accurate biomarker of OP exposure compared to acetylcholinesterase activity. In addition, there was an overall decrease in cerebral mitochondrial function in the Chlorpyrifos group when compared to the Control group.

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关键词

Mitochondria, Chlorpyrifos, Basic science, Biomarker

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