A novel antimycin analogue antimycin A2c, derived from marine Streptomyces sp., suppresses HeLa cells via disrupting mitochondrial function and depleting HPV oncoproteins E6/E7.

Weiyi Zhang,Qian Che,Hongsheng Tan,Xin Qi,Dehai Li,Tianjiao Zhu,Ming Liu

Life sciences（2023）

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摘要

This present work revealed that this novel marine derived antimycin alkaloid could target the mitochondria and subsequently degrade HPV E6/E7 oncoproteins, and have potential application in the design and development of lead compound for cervical cancer cells, as well as the development for tool compounds to dissect E6/E7 functions.

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AE,AMA,AMPK,ANOVA,C-cas3,C-cas9,C-PARP,Cat,DCF,HPVs,Rho 123,IP,MMP,PBS,PVDF,ROS,SDS-PAGE,Ub-E6,UPS

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