Increased frequency and quantity of mucosal and plasma cytomegalovirus replication among Ugandan Adults Living with HIV.

Elisabeth McClymont,Jeffrey Bone,Jackson Orem,Fred Okuku,Mary Kalinaki,Misty Saracino,Meei-Li Huang,Stacy Selke,Anna Wald,Lawrence Corey,Corey Casper,Isabelle Boucoiran,Christine Johnston,Soren Gantt

PloS one（2023）

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摘要

Mucosal and systemic CMV replication occurs at higher levels in PLWH than people without HIV, particularly oral shedding, which is a major mode of CMV transmission. Increased CMV replication despite relatively preserved CD4+ T-cell counts suggests that additional interventions are required to improve CMV control in PLWH.

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plasma cytomegalovirus replication,hiv,ugandan adults

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