Cigarette smoke stimulates clonal expansion of Jak2 V617F and Tet2 -/- cells.

Gajalakshmi Ramanathan,Jane H Chen,Nitya Mehrotra, Tiffany Trieu, Aaron Huang, Eduard Mas,Jessica E Monterrosa Mena,Bishop Bliss,David A Herman,Michael T Kleinman,Angela G Fleischman

Frontiers in oncology（2023）

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摘要

Altogether, these findings demonstrate that CS results in an inflamed bone marrow environment that provides a selection pressure for existing CHIP mutations such as Jak2V617F and Tet2 loss-of-function.

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关键词

inflammation, myeloproliferative neoplasm, reactive oxygen species, cigarette smoke, clonal hematopoiesis

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