UVA LED Light Promoted Cross‐Coupling of Tertiary α‐Silylamines with 1‐Iodoalkynes

A synthetic strategy that exploits the formation of an electron donor‐acceptor (EDA) complex between a tertiary α‐ silylamine and 1‐iodoalkyne under UVA LED (light emitting diode) light ( λ max =365 nm) to prepare propargyl amines is described. The site‐ and chemoselective synthetic method was shown to tolerate a wide range of functional groups to give the α ‐alkynylation product in good to excellent yields. The usefulness of the C(sp)–C(sp 3 ) bond formation protocol was also exemplified by the late‐stage functionalisation of a variety of natural products and bioactive compounds.