Anti-fungal role for type I IFN as dectin-1 triggers non-pathogenic T(H)17 cell development

Sonja I. Gringhuis,Teunis B. H. Geijtenbeek

NATURE IMMUNOLOGY（2022）

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摘要

The fungal pathogen receptor dectin-1 instructs the development of non-pathogenic T(H)17 cells via TGF beta activation. This process requires strict control of the expression of type I interferon to ensure a delicate balance in the expression of its effector genes that control the release of active TGF beta.

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