Neuroanatomical predictors of problematic alcohol consumption in adolescents: a systematic review of longitudinal studies

Aims This study aimed to systematically review the literature on neuroanatomical predictors of future problematic drinking in adolescents. Methods Using PRISMA guidelines, a systematic review was conducted to evaluate neuroanatomical predictors of problematic alcohol consumption in adolescents. EMBASE, MEDLINE, and PsycINFO databases were searched from inception to 6 January 2023. Studies were included if they were original, had a prospective design, had a sample size of at least 12, had a follow-up period of at least 1 year, had at least one structural neuroimaging scan before 18 with no prior alcohol use, and had alcohol use as the primary outcome. Studies were excluded if they had animals only and were not in English. Risk of bias was conducted using the CASP tool. Results Out of 1412 studies identified, 19 studies met the criteria, consisting of 11 gray matter (n = 4040), 5 white matter (n = 319), and 3 assessing both (n = 3608). Neuroanatomical predictors of future problematic drinking in adolescents were reported to be distributed across various brain regions such as the orbitofrontal cortex and paralimbic regions. However, the findings were largely heterogeneous. Conclusions This is the first systematic review to map out the existing literature on neuroanatomical predictors of problematic drinking in adolescents. Future research should focus on the aforementioned regions to determine their role in predicting future problematic drinking with more certainty. Short Summary: A PRISMA systematic review was conducted to evaluate neuroanatomical predictors of problematic alcohol consumption in adolescents. Nineteen studies met the inclusion criteria. Neuroanatomical predictors of future problematic drinking in adolescents were distributed across various brain regions including the orbitofrontal cortex and paralimbic regions. However, the findings were largely heterogeneous.