Inhibition of cystathionine-gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles.

Maria Peleli,Kristina S Lyngso,Frantz Rom Poulsen,Pernille B L Hansen,Andreas Papapetropoulos,Jane Stubbe

Acta physiologica (Oxford, England)（2023）

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摘要

CSE contributes to the K -induced vasoconstriction via a mechanism involving H S, eNOS, and sGC whereas the secondary dilatation is regulated by eNOS and sGC but not by CSE.

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关键词

contractility, cystathionine-gamma lyase, endothelial NO synthase, hydrogen sulfide, intracerebral arterioles, soluble guanylate cyclase

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