Effect of X-ray irradiation combined with PD-1 inhibitor treatment on lung tissue injury in mice.

Leili Wang,Weidong Zhao, Xin Ning,Cailan Wang,Shixiong Liang

International immunopharmacology（2023）

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摘要

Lung injury and pulmonary fibrosis were induced by whole chest X-ray irradiation in mice, and PD-1 inhibitor could aggravate lung injury and pulmonary fibrosis in mice. Thus, radiotherapy combined with PD-1 inhibitors may affect the immune inflammatory microenvironment in the lung tissues of mice by activating TGF-β1/Samd3 and cGAS/STING signaling pathways, thus aggravating lung tissue damage induced by radiation.

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关键词

RT,PD-1 inhibitors,Lung injury,TGF-β1,Smad3,cGAS,STING

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