Subcutaneous and intramuscular administration of a SARS-CoV-2 vaccine are similarly effective in generating a humoral response in domestic goats (Capra hircus).

The 2 vaccination protocols (SC 21 days apart and IM 28 days apart) were similarly effective in mounting serum antibody response in goats. The SC route of administration appeared to have a more rapid onset of immunity, while the IM route may have produced a longer duration of immunity. These data may be useful in determining appropriate SARS-CoV-2 vaccination schedules in ruminants.