Preclinical PK investigation of a novel IDO1/TDO dual inhibitor-SHR9146 in mouse plasma and tissues by LC-MS/MS.

Mei Xiao, Kan Zhong, Li Guo,Wei Li,Xiaoli Wang, Zhenjun Qiu,Taijun Hang

Frontiers in oncology（2023）

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摘要

The method was simple, sensitive, accurate, and specific and was successfully applied for the preclinical pharmacokinetic and tissue distribution study of SHR9146 in mice. The results showed that SHR9146 had dose-independent kinetics in mice via oral administration and was absorbed rapidly and distributed widely. The study provides a good basis for further drug development assessment.

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关键词

SHR9146, IDO1, TDO inhibitor, pharmacokinetics, tissue distribution, LC-MS, MS

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