A method for chronic and semi-chronic microelectrode array implantation in deep brain structures using image guided neuronavigation

Borna Mahmoudian, Hitarth Dalal,Jonathan Lau,Benjamin Corrigan,Mohamad Abbass,Kevin Barker,Adam Rankin,Elvis C.S. Chen,Terry Peters,Julio C. Martinez-Trujillo

Journal of Neuroscience Methods（2023）

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摘要

•Image-guided targeting of subcortical structures in large animal models for chronic microelectrode implantation.•Incorporation of stable screw fiducials into a cranial cap allowed for subject-image registration.•Reduced craniotomy footprint (2.4 mm) for chamber implantation decreased the chance of infections.•In-house 3D-printed microdrive extended the chamber usage to semi-chronic applications.

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关键词

Image guided neuronavigation,Microelectrode implantation,Non-human primates,Deep brain structures,Electrophysiology,Stereoelectroencephalography (SEEG)

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