Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Rossitza N. Irobalieva,Ioannis Manolaridis,Scott M. Jackson,Dongchun Ni,Els Pardon,Henning Stahlberg,Jan Steyaert,Kaspar P. Locher

Journal of molecular biology（2023）

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摘要

•Nanobodies can bind to ABCG2 allosterically and modulate its function.•Inhibitory nanobodies can prevent transport without interfering with the substrate binding pocket.•Modulation by nanobodies could be a valuable tool for studies of various membrane transporters.

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关键词

Cryo-EM,inhibitor,structural biology,allosteric modulators,BCRP

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