Antileishmanial activities of three chalcone derivatives and their association with plasma membrane rigidity as assessed by EPR spectroscopy

Ellyêssa Nascimento Borges,Lais Alonso,Murilo Barros Silveira,Rodolfo Bento Balbinot,Celso V. Nakamura,André Luis Batista da Rocha, Evilanna Lima Arruda, Gabriel Franco dos Santos,Boniek G. Vaz, Christian Dias Gomides,Luciano Morais Lião,Ricardo Menegatti,Antonio Alonso

Journal of Molecular Structure（2023）

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摘要

•LQFM332 causes cell membrane rigidity, as detected by EPR spectroscopy.•Membrane rigidity was associated with antileishmanial activity.•EPR spectra suggest that chalcone derivatives cause oxidation in membrane proteins.

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关键词

Leishmania, Chalcone, Membrane fluidity, Electron paramagnetic resonance

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