A J-shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross-sectional study.

Ying Liu,Jingyu Wang, Fang Xu,Shuang Zhang,Shanshan Cui,Yongmei Li,Xiaoyu Wang, Hui Zheng, Junfeng Li,Yan Kong,Juhong Yang,Xia Jiang,Baocheng Chang

Diabetes, obesity & metabolism（2023）

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摘要

A J-shaped relationship between circulating ketone level and DKD risk in patients with T2D was determined. Circulating βOHB in the range of 0.12-0.30 mM was associated with a lower risk of DKD. Further studies are warranted to verify the causality and to elucidate the underlying mechanisms.

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关键词

diabetic kidney disease,ketone body,urinary albumin excretion,β-hydroxybutyric acid

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