Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in isolated mouse ventricular myocytes.

Daniel Tarnowski,Anna-Lena Feder,Maximilian Trum, Klaus-Georg Kreitmeier, Laura Stengel,Lars S Maier,Can Martin Sag

Frontiers in cardiovascular medicine（2023）

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摘要

Inhibition of BTK by Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in adult ventricular mouse myocytes in the face of disrupted Akt signaling and absent SERCA2a upregulation.

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关键词

Ibrutinib, IGF-1, EC-coupling, heart failure, SR Ca handling

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